2-[4-(4-Methylphenylsulfonyl)piperazin-1-yl]-1-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)ethanone
نویسندگان
چکیده
In the title thienopyridine derivative, C(20)H(25)N(3)O(3)S(2), the piperazine ring exhibits a chair conformation and the tetra-hydro-pyridine ring exhibits a half-chair conformation. The folded conformation of the mol-ecule is defined by the N-C-C-N torsion angle of -70.20 (2) °. Inter-molecular C-H⋯S and C-H⋯O hydrogen bonds help to establish the packing.
منابع مشابه
1-(4,5,6,7-Tetrahydrothieno[3,2-c]pyridin-5-yl)-2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethanone
In the title mol-ecule, C(20)H(22)F(3)N(3)OS, the piperazine ring has a chair conformation, and the N-C(=O)-C-N torsion angle is -59.42 (14)°. In the crystal, weak C-H⋯O and C-H⋯π inter-actions link the mol-ecules into layers parallel to (101).
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The title compound, C(19)H(22)N(4)O(3)S, comprises a thienopyridine moiety which is characteristic for anti-platelet agents of the clopidogrel class of compounds. In the crystal, inversion dimers are formed through pairs of C-H⋯O inter-actions. The benzene ring plane and the nitro plane are almost coplanar, with a dihedral angle of 0.83 (2)°. The piperazine ring adopts a chair conformation.
متن کاملTitle : Human intestinal Raf kinase inhibitor protein , RKIP , catalyzes prasugrel as a bioactivation hydrolase
250 words Introduction: 315 words Discussion: 950 words Abbreviations: HPLC, high performance liquid chromatography; LC-MS/MS, liquid chromatography/tandem mass spectrometry; RKIP, Raf1-kinase inhibitor protein; HEPES, 2-[4-(2-Hydroxyethyl)-1-piperazinyl]ethanesulfonic acid; DMSO, dimethylsulfoxide ; Tris, tris(hydroxymethyl)aminomethane, SDS-PAGE, sodium dodecyl sulfate-polyacrylamide gel elec...
متن کاملRaf kinase inhibitor protein , RKIP , catalyzes prasugrel as a bioactivation hydrolase
250 words Introduction: 315 words Discussion: 950 words Abbreviations: HPLC, high performance liquid chromatography; LC-MS/MS, liquid chromatography/tandem mass spectrometry; RKIP, Raf1-kinase inhibitor protein; HEPES, 2-[4-(2-Hydroxyethyl)-1-piperazinyl]ethanesulfonic acid; DMSO, dimethylsulfoxide ; Tris, tris(hydroxymethyl)aminomethane, SDS-PAGE, sodium dodecyl sulfate-polyacrylamide gel elec...
متن کامل2-Chloro-1-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)ethanone
In the title compound, C(9)H(10)ClNOS, the dihedral angle between the planar thio-phene ring and 2-chloro-ethane moiety (r.m.s deviations of 0.003 and 0.015 Å, respectively) is 45.79 (6)°. The tetra-hydro-pyridine ring adopts a half-chair conformation. The crystal packing reveals inter-molecular C-H⋯O inter-actions.
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